Literature DB >> 16298376

High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts.

Nadja B Cech1, Maqueita S Eleazer, Lawresa T Shoffner, Mark R Crosswhite, Amanda C Davis, Ashley M Mortenson.   

Abstract

Extracts of the plant Echinacea purpurea are widely used for medicinal purposes. Effective quality control of these extracts requires rapid methods to determine their chemical composition. A new method for analysis of caffeic acid derivatives and alkamides from Echinacea extracts has been developed. With this method, isomeric isobutylamides and 2-methylbutylamides can be distinguished, a capability that previously published methods have lacked. Quantitative analyses carried out with this method on E. purpurea extracts that have been stored for 18 months indicate that they contain caftaric acid, cichoric acid, and undeca-2Z,4E-diene-8,10-diynoic acid isobutylamide at concentrations of 0.7, 0.71 and 2.0mg/mL, respectively.

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Year:  2005        PMID： 16298376     DOI： 10.1016/j.chroma.2005.11.008

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  12 in total

1.  Echinacea purpurea extracts modulate murine dendritic cell fate and function.

Authors:  Jenna M Benson; Amanda J Pokorny; Ava Rhule; Cynthia A Wenner; Vamsikrishna Kandhi; Nadja B Cech; David M Shepherd
Journal:  Food Chem Toxicol       Date:  2010-02-10       Impact factor: 6.023

2.  Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Authors:  Travis V Gulledge; Nicholas M Collette; Emily Mackey; Stephanie E Johnstone; Yasamin Moazami; Daniel A Todd; Adam J Moeser; Joshua G Pierce; Nadja B Cech; Scott M Laster
Journal:  J Ethnopharmacol       Date:  2017-10-14       Impact factor: 4.360

3.  Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS.

Authors:  Kevin Spelman; Matthew H Wetschler; Nadja B Cech
Journal:  J Pharm Biomed Anal       Date:  2009-02-20       Impact factor: 3.935

4.  Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.

Authors:  Gregory M Raner; Sean Cornelious; Kamalika Moulick; Yingqing Wang; Ashley Mortenson; Nadja B Cech
Journal:  Food Chem Toxicol       Date:  2007-06-15       Impact factor: 6.023

5.  Endogenous levels of Echinacea alkylamides and ketones are important contributors to the inhibition of prostaglandin E2 and nitric oxide production in cultured macrophages.

Authors:  Carlie A LaLone; Ludmila Rizshsky; Kimberly D P Hammer; Lankun Wu; Avery K S Solco; Manyu Yum; Basil J Nikolau; Eve S Wurtele; Patricia A Murphy; Meehye Kim; Diane F Birt
Journal:  J Agric Food Chem       Date:  2009-10-14       Impact factor: 5.279

Review 6.  Echinacea purpurea: Pharmacology, phytochemistry and analysis methods.

Authors:  Azadeh Manayi; Mahdi Vazirian; Soodabeh Saeidnia
Journal:  Pharmacogn Rev       Date:  2015 Jan-Jun

7.  Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria.

Authors:  Daniel A Todd; Travis V Gulledge; Emily R Britton; Martina Oberhofer; Martha Leyte-Lugo; Ashley N Moody; Tatsiana Shymanovich; Laura F Grubbs; Monika Juzumaite; Tyler N Graf; Nicholas H Oberlies; Stanley H Faeth; Scott M Laster; Nadja B Cech
Journal:  PLoS One       Date:  2015-05-01       Impact factor: 3.240

8.  Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model.

Authors:  Valentina Maggini; Marinella De Leo; Alessio Mengoni; Eugenia Rosaria Gallo; Elisangela Miceli; Rose Vanessa Bandeira Reidel; Sauro Biffi; Luisa Pistelli; Renato Fani; Fabio Firenzuoli; Patrizia Bogani
Journal:  Sci Rep       Date:  2017-12-05       Impact factor: 4.379

9.  N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography-mass spectrometry.

Authors:  Lieselotte Veryser; Lien Taevernier; Evelien Wynendaele; Yannick Verheust; Ann Dumoulin; Bart De Spiegeleer
Journal:  J Pharm Anal       Date:  2016-09-24

10.  The influence of Echinacea purpurea leaf microbiota on chicoric acid level.

Authors:  Valentina Maggini; Marinella De Leo; Carlotta Granchi; Tiziano Tuccinardi; Alessio Mengoni; Eugenia Rosaria Gallo; Sauro Biffi; Renato Fani; Luisa Pistelli; Fabio Firenzuoli; Patrizia Bogani
Journal:  Sci Rep       Date:  2019-07-26       Impact factor: 4.379
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