Literature DB >> 1629818

Protective effects of ciprofloxacin against type II collagen induced arthritis in rats.

M Breban1, C Fournier, M A Gougerot-Pocidalo, M Muffat-Joly, J J Pocidalo.   

Abstract

Ciprofloxacin, a new fluoroquinolone antibiotic, inhibits the in vitro production of interleukin 1 beta and tumor necrosis factor alpha by monocytes. We investigated its activity against type II collagen induced arthritis in rats. It exerted a dose dependent preventive effect at 50 and 75 mg/kg/day against clinical and histologic features of collagen induced arthritis without any influence on the production of anticollagen antibodies and alpha 1-acid glycoprotein. This effect was reversible after early removal of the treatment. Ciprofloxacin did not inhibit collagen induced arthritis in adrenalectomized rats but rather caused an exacerbation of the disease. Its effect was not modified by the simultaneous administration of an antiglucocorticoid, RU 40555.

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Year:  1992        PMID： 1629818

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  7 in total

Review 1.  Bacteria-Triggered reactive arthritis: implications for antibacterial treatment.

Authors:  A Toivanen
Journal:  Drugs       Date:  2001       Impact factor: 9.546

2.  Soluble complement receptor one (sCR1) inhibits the development and progression of rat collagen-induced arthritis.

Authors:  R M Goodfellow; A S Williams; J L Levin; B D Williams; B P Morgan
Journal:  Clin Exp Immunol       Date:  2000-01       Impact factor: 4.330

3.  Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death.

Authors:  Juliann G Kiang; Bradley R Garrison; Joan T Smith; Risaku Fukumoto
Journal:  Mol Cell Biochem       Date:  2014-05-07       Impact factor: 3.396

4.  Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, cloricromene.

Authors:  S Tranchina; S Bernasconi; E Dejana; A Del Maschio
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739

5.  Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma.

Authors:  Risaku Fukumoto; Lynnette H Cary; Nikolai V Gorbunov; Eric D Lombardini; Thomas B Elliott; Juliann G Kiang
Journal:  PLoS One       Date:  2013-03-08       Impact factor: 3.240

6.  Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma.

Authors:  Risaku Fukumoto; True M Burns; Juliann G Kiang
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240

7.  Ciprofloxacin Enhances TRAIL-Induced Apoptosis in Lung Cancer Cells by Upregulating the Expression and Protein Stability of Death Receptors through CHOP Expression.

Authors:  Eun Jin Lim; Yu Jeong Yoon; Jeonghoon Heo; Tae Hwa Lee; Young-Ho Kim
Journal:  Int J Mol Sci       Date:  2018-10-16       Impact factor: 5.923
  7 in total

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