| Literature DB >> 16298129 |
Yannick Rose1, Stéphane Ciblat, Ranga Reddy, Adam C Belley, Evelyne Dietrich, Dario Lehoux, Geoffrey A McKay, Hugo Poirier, Adel Rafai Far, Daniel Delorme.
Abstract
The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new dGTP competitive inhibitors displayed good levels of in vitro inhibition and antibacterial activity against Staphylococcus aureus. A new class of dATP competitive inhibitors, 6-substituted-2-amino-5-alkyl-pyrimidin-4-ones, whose antibacterial activity was unaffected by serum, were identified.Entities:
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Year: 2005 PMID： 16298129 DOI： 10.1016/j.bmcl.2005.11.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823