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Literature DB >> 16297622

Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.

Vandana Srivastava¹, Arvind S Negi, J K Kumar, Uzma Faridi, Brijesh S Sisodia, M P Darokar, Suaib Luqman, S P S Khanuja.

Abstract

3',4',5'-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 microg/ml concentrations, respectively, in the in vitro MTT assay.

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Year: 2005 PMID： 16297622 DOI： 10.1016/j.bmcl.2005.10.105

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Synthesis of novel and diverse naphtho[1,2-b]furans by phosphine-catalyzed [3+2] annulation of activated 1,4-naphthoquinones and acetylenecarboxylates.

Authors: Likai Xia; Krishna Bahadur Somai Magar; Yong Rok Lee
Journal: Mol Divers Date: 2014-10-01 Impact factor: 2.943

6. Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds.

Authors: Soumitra Agasti; Soham Maity; Kalman J Szabo; Debabrata Maiti
Journal: Adv Synth Catal Date: 2015-07-14 Impact factor: 5.837

6 in total

Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.

1. Synthesis of novel and diverse naphtho[1,2-b]furans by phosphine-catalyzed [3+2] annulation of activated 1,4-naphthoquinones and acetylenecarboxylates.

2. An Easy Access to Furan-Fused Polyheterocyclic Systems.

3. First synthesis of 2-(benzofuran-2-yl)-6,7-methylene dioxyquinoline-3-carboxylic acid derivatives.

4. Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans.

5. Determination of key residues in MRGPRX2 to enhance pseudo-allergic reactions induced by fluoroquinolones.

6. Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds.