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Literature DB >> 16297436

Pathophysiology of synuclein aggregation in Lewy body disease.

Elizabeta B Mukaetova-Ladinska¹, Ian G McKeith.

Abstract

We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of alpha-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered alpha-synuclein metabolism, mechanisms leading to alpha-synuclein fibril formation (self-polymerisation, alpha-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal alpha-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease.

Entities: Chemical

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Year: 2005 PMID： 16297436 DOI： 10.1016/j.mad.2005.09.014

Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432

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Cited

20 in total

1. Cognitive status correlates with white matter alteration in Parkinson's disease.

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Journal: Hum Brain Mapp Date: 2011-04-14 Impact factor: 5.038

2. Differential nigral expression of bcl-2 protein family in the pure and common forms of Dementia with Lewy bodies: relevance for dopaminergic neuronal vulnerability.

Authors: M Saldaña; E Aguilar; M Bonastre; C Marin
Journal: J Neural Transm (Vienna) Date: 2007-07-04 Impact factor: 3.575

3. Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.

Authors: Piriya Wongkongkathep; Jong Yoon Han; Tae Su Choi; Sheng Yin; Hugh I Kim; Joseph A Loo
Journal: J Am Soc Mass Spectrom Date: 2018-06-27 Impact factor: 3.109

Pathophysiology of synuclein aggregation in Lewy body disease.

1. Cognitive status correlates with white matter alteration in Parkinson's disease.

2. Differential nigral expression of bcl-2 protein family in the pure and common forms of Dementia with Lewy bodies: relevance for dopaminergic neuronal vulnerability.

3. Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.

Review 4. Diagnosis and treatment of Parkinson disease: molecules to medicine.

5. Metabolic connectomics targeting brain pathology in dementia with Lewy bodies.

6. Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.

7. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

8. Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases.

9. Cerebrospinal fluid biomarkers for dementia with lewy bodies.

10. DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells.