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Literature DB >> 16296726

Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery.

Monjed Shakweh¹, Gilles Ponchel, Elias Fattal.

Abstract

Particle uptake by Peyer's patches offers the possibility of tailoring vaccines that can be delivered orally. However, particle uptake by the follicle-associated epithelium in the gastrointestinal tract depends on several different factors that are the physicochemical properties of the particles, the physiopathological state of the animal, the analytical method used to evaluate the uptake and finally the experimental model. These parameters do not allow a clear idea about the optimal conditions to target the Peyer's patches. The goal of this review is to clarify the role of each factor in this uptake.

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Year: 2004 PMID： 16296726 DOI： 10.1517/17425247.1.1.141

Source DB: PubMed Journal: Expert Opin Drug Deliv ISSN： 1742-5247 Impact factor: 6.648

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Cited

29 in total

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4. Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice.

Authors: Lauren E Hudson; Taryn P Stewart; Milo B Fasken; Anita H Corbett; Tracey J Lamb
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10. Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury.

Authors: Mandy B Esch; Gretchen J Mahler; Tracy Stokol; Michael L Shuler
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Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery.

Review 1. Past, present, and future technologies for oral delivery of therapeutic proteins.

Review 2. Recent advances in oral vaccine development: yeast-derived β-glucan particles.

Review 3. Modulating the immune system through nanotechnology.

4. Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice.

5. Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery.

Review 6. Approaches for enhancing oral bioavailability of peptides and proteins.

7. Evidence of oral translocation of anionic G6.5 dendrimers in mice.

Review 8. Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles.

Review 9. Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery.

10. Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury.