OBJECTIVE: Chronology poorly predicts biological age (BA) or physiologic reserve (PR). An objective approach to the heterogeneity of aging would greatly help clinical decision making in the elderly. MATERIALS AND METHODS: The first pilot study evaluated 130 "healthy" volunteers, ages 70 to 95 years. A summary BA/PR index was developed, using measures of endurance, strength, flexibility, balance, cognition, depression, comorbidity, and exercise. The second study applied the BA/PR concept to prediction of death after a first elective coronary artery bypass graft, using a Veterans Administration database. RESULTS: The BA/PR index was a better predictor of 3-year functional outcomes and death than was chronological age. In the coronary artery bypass graft study, the inclusion of BA/PR variables significantly improved prediction of 6-month and long-term death for Veterans Administration patients. CONCLUSIONS: The usefulness of a biological age (BA/PR) approach in predicting outcomes in the elderly was supported. Needed research should develop tools for routine "tracking" of the aging process.
OBJECTIVE: Chronology poorly predicts biological age (BA) or physiologic reserve (PR). An objective approach to the heterogeneity of aging would greatly help clinical decision making in the elderly. MATERIALS AND METHODS: The first pilot study evaluated 130 "healthy" volunteers, ages 70 to 95 years. A summary BA/PR index was developed, using measures of endurance, strength, flexibility, balance, cognition, depression, comorbidity, and exercise. The second study applied the BA/PR concept to prediction of death after a first elective coronary artery bypass graft, using a Veterans Administration database. RESULTS: The BA/PR index was a better predictor of 3-year functional outcomes and death than was chronological age. In the coronary artery bypass graft study, the inclusion of BA/PR variables significantly improved prediction of 6-month and long-term death for Veterans Administration patients. CONCLUSIONS: The usefulness of a biological age (BA/PR) approach in predicting outcomes in the elderly was supported. Needed research should develop tools for routine "tracking" of the aging process.
Authors: Correne A DeCarlo; Holly A Tuokko; Dorothy Williams; Roger A Dixon; Stuart W S MacDonald Journal: Ageing Res Rev Date: 2014-09-30 Impact factor: 10.895
Authors: Jinze Xu; Arnold Y Seo; Darya A Vorobyeva; Christy S Carter; Stephen D Anton; Angela M S Lezza; Christiaan Leeuwenburgh Journal: PLoS One Date: 2010-05-11 Impact factor: 3.240
Authors: Giedre Zurauskaite; Marc Meier; Alaadin Voegeli; Daniel Koch; Sebastian Haubitz; Alexander Kutz; Luca Bernasconi; Andreas Huber; Mario Bargetzi; Beat Mueller; Philipp Schuetz Journal: PLoS One Date: 2018-01-17 Impact factor: 3.240