| Literature DB >> 16295543 |
Dominique Laurent1, Francine Baumann, Anne Gaelle Benoit, Alain Mortelecqe, Narong Nitatpattana, Isabelle Desvignes, Cécile Debitus, Manola Laille, Jean-Paul Gonzalez, Eliane Chungue.
Abstract
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.Entities:
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Year: 2005 PMID： 16295543
Source DB: PubMed Journal: Southeast Asian J Trop Med Public Health ISSN： 0125-1562 Impact factor: 0.267