Literature DB >> 16294036

New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability.

Xialu Li1, James L Manley.   

Abstract

ASF/SF2 is a well-studied SR protein that plays important roles in premRNA splicing and other aspects of RNA metabolism. Genetic inactivation experiments have revealed the fundamental roles of ASF/SF2 and other SR proteins in cell viability and animal development. However, the nature of the events triggered by in vivo depletion of ASF/SF2 remained largely elusive. Recently, we have demonstrated a significant function of ASF/SF2 in the maintenance of genome stability by preventing the formation of R loops, which provided new insights into the essential roles of ASF/SF2 in cellular physiology.

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Year:  2005        PMID： 16294036     DOI： 10.4161/cc.4.12.2210

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  14 in total

1.  Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.

Authors:  Deepankar Roy; Zheng Zhang; Zhengfei Lu; Chih-Lin Hsieh; Michael R Lieber
Journal:  Mol Cell Biol       Date:  2010-01       Impact factor: 4.272

Review 2.  The function of spliceosome components in open mitosis.

Authors:  Jennifer C Hofmann; Alma Husedzinovic; Oliver J Gruss
Journal:  Nucleus       Date:  2010-08-13       Impact factor: 4.197

3.  Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity.

Authors:  Takayuki Katsuyama; Hao Li; Denis Comte; George C Tsokos; Vaishali R Moulton
Journal:  J Clin Invest       Date:  2019-12-02       Impact factor: 14.808

4.  G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter.

Authors:  Deepankar Roy; Michael R Lieber
Journal:  Mol Cell Biol       Date:  2009-03-23       Impact factor: 4.272

5.  The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.

Authors:  François Juge; Céline Fernando; Weronika Fic; Jamal Tazi
Journal:  PLoS Genet       Date:  2010-09-16       Impact factor: 5.917

6.  Phosphorylation meets nuclear import: a review.

Authors:  Jonathan D Nardozzi; Kaylen Lott; Gino Cingolani
Journal:  Cell Commun Signal       Date:  2010-12-23       Impact factor: 5.712

Review 7.  Defective splicing, disease and therapy: searching for master checkpoints in exon definition.

Authors:  Emanuele Buratti; Marco Baralle; Francisco E Baralle
Journal:  Nucleic Acids Res       Date:  2006-07-19       Impact factor: 16.971

8.  A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes.

Authors:  Shiri Eshar; Eric Allemand; Ariel Sebag; Fabian Glaser; Christian Muchardt; Yael Mandel-Gutfreund; Rotem Karni; Ron Dzikowski
Journal:  Nucleic Acids Res       Date:  2012-08-09       Impact factor: 16.971

9.  Detecting splicing variants in idiopathic pulmonary fibrosis from non-differentially expressed genes.

Authors:  Nan Deng; Cecilia G Sanchez; Joseph A Lasky; Dongxiao Zhu
Journal:  PLoS One       Date:  2013-07-02       Impact factor: 3.240

10.  Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia.

Authors:  Xianfeng Zha; Xiaojuan Yan; Qi Shen; Yuping Zhang; Xiuli Wu; Shaohua Chen; Bo Li; Lijian Yang; Suxia Geng; Jianyu Weng; Xin Du; Yangqiu Li
Journal:  J Hematol Oncol       Date:  2012-12-10       Impact factor: 17.388
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