Literature DB >> 16293093

Degradable, drug-eluting stents: a new frontier for the treatment of coronary artery disease.

Joachim Kohn1, Joan Zeltinger.   

Abstract

This article reviews the clinical use of stents in the treatment of coronary artery disease and the rationale for the use of degradable, drug-eluting polymer stents. The authors note the challenges of using off-the-shelf polymers for the development of degradable stents, as well as the interplay between polymer properties and a functional stent design. Drug-eluting metal stents are the most significant advancement in the treatment of coronary artery disease, and have significantly reduced the occurrence of in-stent restenosis after placement. Some regard drug-eluting metal stents as the final technologic advancement in the treatment of coronary artery disease, others consider the future development of degradable, drug-eluting stents as the next logical step.

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Year:  2005        PMID: 16293093     DOI: 10.1586/17434440.2.6.667

Source DB:  PubMed          Journal:  Expert Rev Med Devices        ISSN: 1743-4440            Impact factor:   3.166


  13 in total

Review 1.  Degradable and bioresorbable polymers in surgery and in pharmacology: beliefs and facts.

Authors:  Michel Vert
Journal:  J Mater Sci Mater Med       Date:  2008-09-25       Impact factor: 3.896

2.  Thin Film Elastic Modulus of Degradable Tyrosine-Derived Polycarbonate Biomaterials and Their Blends.

Authors:  Khaled A Aamer; Christopher M Stafford; Lee J Richter; Joachim Kohn; Matthew L Becker
Journal:  Macromolecules       Date:  2009-01-22       Impact factor: 5.985

3.  Study of nanoscale structures in hydrated biomaterials using small-angle neutron scattering.

Authors:  A Luk; N S Murthy; W Wang; R Rojas; J Kohn
Journal:  Acta Biomater       Date:  2011-12-24       Impact factor: 8.947

4.  Microphase separation in copolymers of hydrophilic PEG blocks and hydrophobic tyrosine-derived segments using simultaneous SAXS/WAXS/DSC.

Authors:  N S Murthy; W Wang; J Kohn
Journal:  Polymer (Guildf)       Date:  2010-08-04       Impact factor: 4.430

5.  Impact of polymer-bound iodine on fibronectin adsorption and osteoblast cell morphology in radiopaque medical polymers: tyrosine-derived polycarbonate blends as a model system.

Authors:  Khaled A Aamer; Kirsten L Genson; Joachim Kohn; Matthew L Becker
Journal:  Biomacromolecules       Date:  2009-09-14       Impact factor: 6.988

6.  Calcium phosphate enriched synthetic tyrosine-derived polycarbonate - dicalcium phosphate dihydrate polymer scaffolds for enhanced bone regeneration.

Authors:  Shruti Saxena; Wei Chang; Amir Fakhrzadeh; N Sanjeeva Murthy; Weibo Zhang; Joachim Kohn; Pamela C Yelick
Journal:  Materialia (Oxf)       Date:  2020-02-06

7.  Structure of biodegradable films at aqueous surfaces: X-ray diffraction and spectroscopy studies of polylactides and tyrosine-derived polycarbonates.

Authors:  Wenjie Wang; N Sanjeeva Murthy; Ivan Kuzmenko; Nathaniel A Anderson; David Vaknin
Journal:  Langmuir       Date:  2013-08-26       Impact factor: 3.882

Review 8.  Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents.

Authors:  Hui Ying Ang; Ying Ying Huang; Soo Teik Lim; Philip Wong; Michael Joner; Nicolas Foin
Journal:  J Thorac Dis       Date:  2017-08       Impact factor: 2.895

9.  Interplay of anionic charge, poly(ethylene glycol), and iodinated tyrosine incorporation within tyrosine-derived polycarbonates: Effects on vascular smooth muscle cell adhesion, proliferation, and motility.

Authors:  Patrick A Johnson; Arnold Luk; Aleksey Demtchouk; Hiral Patel; Hak-Joon Sung; Matthew D Treiser; Simon Gordonov; Larisa Sheihet; Das Bolikal; Joachim Kohn; Prabhas V Moghe
Journal:  J Biomed Mater Res A       Date:  2010-05       Impact factor: 4.396

10.  Design of barrier coatings on kink-resistant peripheral nerve conduits.

Authors:  Basak Acan Clements; Jared Bushman; N Sanjeeva Murthy; Mindy Ezra; Christopher M Pastore; Joachim Kohn
Journal:  J Tissue Eng       Date:  2016-02-05       Impact factor: 7.813

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