BACKGROUND: In congestive heart failure (CHF), it is unknown whether race affects mortality and whether the effect of treatments differs by race. METHODS: This study was a post hoc analysis of data from the DIG study that evaluated the effect of digoxin on morbidity and mortality in CHF. RESULTS: Investigators followed 897 black and 6660 white participants for a mean of 37 months. Compared with whites, blacks were younger (60 +/- 13 vs 65 +/- 11 years). Total mortality was 34.2% in blacks and 33.6% in whites; hospitalization for worsening CHF occurred in 39% of blacks and 28% of whites. Cox regressions with race as the only covariate showed no effect of race on risk for death (relative risk = 1.04, 95% CI 0.93-1.18, P = .49) but an increase in CHF hospitalization in blacks (relative risk = 1.52, 95% CI 1.35-1.70, P = .0001). Multivariate Cox regression showed no difference by race in risk for death or death/hospitalization for CHF and no difference in the effect of digoxin on either end point. CONCLUSION: Race is not an independent predictor of mortality in CHF. The effect of digoxin on morbidity and mortality in CHF does not differ in blacks and whites.
BACKGROUND: In congestive heart failure (CHF), it is unknown whether race affects mortality and whether the effect of treatments differs by race. METHODS: This study was a post hoc analysis of data from the DIG study that evaluated the effect of digoxin on morbidity and mortality in CHF. RESULTS: Investigators followed 897 black and 6660 white participants for a mean of 37 months. Compared with whites, blacks were younger (60 +/- 13 vs 65 +/- 11 years). Total mortality was 34.2% in blacks and 33.6% in whites; hospitalization for worsening CHF occurred in 39% of blacks and 28% of whites. Cox regressions with race as the only covariate showed no effect of race on risk for death (relative risk = 1.04, 95% CI 0.93-1.18, P = .49) but an increase in CHF hospitalization in blacks (relative risk = 1.52, 95% CI 1.35-1.70, P = .0001). Multivariate Cox regression showed no difference by race in risk for death or death/hospitalization for CHF and no difference in the effect of digoxin on either end point. CONCLUSION: Race is not an independent predictor of mortality in CHF. The effect of digoxin on morbidity and mortality in CHF does not differ in blacks and whites.
Authors: Jia-Rong Wu; Terry A Lennie; Marla J De Jong; Susan K Frazier; Seongkum Heo; Misook L Chung; Debra K Moser Journal: J Card Fail Date: 2009-12-11 Impact factor: 5.712
Authors: Margaret A Feller; Marjan Mujib; Yan Zhang; O James Ekundayo; Inmaculada B Aban; Gregg C Fonarow; Richard M Allman; Ali Ahmed Journal: Int J Cardiol Date: 2011-05-31 Impact factor: 4.164
Authors: Jia-Rong Wu; Debra K Moser; Mary Kay Rayens; Marla J De Jong; Misook L Chung; Barbara Riegel; Terry A Lennie Journal: Heart Lung Date: 2010 Nov-Dec Impact factor: 2.210
Authors: Jerry H Gurwitz; David J Magid; David H Smith; Grace Hsu; Sue Hee Sung; Larry A Allen; David D McManus; Robert J Goldberg; Alan S Go Journal: Am J Med Date: 2014-12-30 Impact factor: 4.965
Authors: Meena Elanchenny; Arthur J Moss; Scott McNitt; Mehmet Aktas; Slava Polonsky; Wojciech Zareba; Ilan Goldenberg Journal: Ann Noninvasive Electrocardiol Date: 2012-11-22 Impact factor: 1.468
Authors: James Studnicki; Bola F Ekezue; Maka Tsulukidze; Peggy Honoré; Ramal Moonesinghe; John Fisher Journal: Am J Med Qual Date: 2013-03-24 Impact factor: 1.852
Authors: Jia-Rong Wu; George M Holmes; Darren A DeWalt; Aurelia Macabasco-O'Connell; Kirsten Bibbins-Domingo; Bernice Ruo; David W Baker; Dean Schillinger; Morris Weinberger; Kimberly A Broucksou; Brian Erman; Christine D Jones; Crystal W Cene; Michael Pignone Journal: J Gen Intern Med Date: 2013-03-12 Impact factor: 5.128
Authors: Raegan W Durant; Qiana L Brown; Andrea L Cherrington; Lynn J Andreae; Claudia M Hardy; Isabel C Scarinci Journal: Heart Lung Date: 2012-08-21 Impact factor: 2.210