| Literature DB >> 16289879 |
Sung Yun Cho1, Ji Yoen Baek, Sang Sub Han, Seung Kyu Kang, Jae Du Ha, Jin Hee Ahn, Jae Don Lee, Kwang Rok Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Sung Don Yang, Gyu Hwan Yon, Chwang Siek Pak, Joong-Kwon Choi.
Abstract
A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC(50) value and high level of selectivity over other recombinant phosphatases.Entities:
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Year: 2005 PMID： 16289879 DOI： 10.1016/j.bmcl.2005.10.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823