| Literature DB >> 16289857 |
Fernando D Suvire1, Maximiliano Sortino, Vladimir V Kouznetsov, Leonor Y Vargas M, Susana A Zacchino, Uriel Mora Cruz, Ricardo D Enriz.
Abstract
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.Entities:
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Year: 2005 PMID： 16289857 DOI： 10.1016/j.bmc.2005.10.036
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641