BACKGROUND: Alterations in brain metabolism as well as in brain function in different brain areas can be observed in severely depressed patients. METHODS: The present study combined proton magnetic resonance spectroscopy (1H MRS, n=16; healthy controls n=27) and magnetoencephalography (MEG, n=17, controls n=18) of the left auditory cortex in severely depressed inpatients pre- and post successful antidepressive therapy. For MEG recordings, patients were stimulated with trains of 4 successive vowels or 4 sine tones, respectively. For each of the 4 stimuli, the amplitude and latency of the N1m was calculated. As a measure of habituation the decrease of the individual amplitudes of the second, third and fourth N1m compared to the first N1m was calculated. RESULTS: Prior to therapy, a subset of patients presented clearly disturbed auditory processing to stimuli (missing of distinct N1m1 and subsequent habituation; 5 of 17 patients (vowels) and 9/17 (tones, respectively)). After treatment, compared to controls, a normalized habituation pattern was observed in all patients for vowels, but not for tones. In contrast, MRS revealed no significant differences between the metabolite concentrations of patients and healthy controls in both measurements. CONCLUSION: Depression may be accompanied by impaired auditory processing, which seems to improve with reduction in depressive symptoms. Auditory cortical dysfunction probably reflects only a part from more widespread aberrations of brain function occurring with severe mood disorder.
BACKGROUND: Alterations in brain metabolism as well as in brain function in different brain areas can be observed in severely depressedpatients. METHODS: The present study combined proton magnetic resonance spectroscopy (1H MRS, n=16; healthy controls n=27) and magnetoencephalography (MEG, n=17, controls n=18) of the left auditory cortex in severely depressed inpatients pre- and post successful antidepressive therapy. For MEG recordings, patients were stimulated with trains of 4 successive vowels or 4 sine tones, respectively. For each of the 4 stimuli, the amplitude and latency of the N1m was calculated. As a measure of habituation the decrease of the individual amplitudes of the second, third and fourth N1m compared to the first N1m was calculated. RESULTS: Prior to therapy, a subset of patients presented clearly disturbed auditory processing to stimuli (missing of distinct N1m1 and subsequent habituation; 5 of 17 patients (vowels) and 9/17 (tones, respectively)). After treatment, compared to controls, a normalized habituation pattern was observed in all patients for vowels, but not for tones. In contrast, MRS revealed no significant differences between the metabolite concentrations of patients and healthy controls in both measurements. CONCLUSION:Depression may be accompanied by impaired auditory processing, which seems to improve with reduction in depressive symptoms. Auditory cortical dysfunction probably reflects only a part from more widespread aberrations of brain function occurring with severe mood disorder.
Authors: Arnim Johannes Gaebler; Jana Zweerings; Jan Willem Koten; Andrea Anna König; Bruce I Turetsky; Mikhail Zvyagintsev; Klaus Mathiak Journal: Schizophr Bull Date: 2020-01-04 Impact factor: 9.306
Authors: John F Smiley; Troy A Hackett; Cynthia Bleiwas; Eva Petkova; Aleksandar Stankov; J John Mann; Gorazd Rosoklija; Andrew J Dwork Journal: J Chem Neuroanat Date: 2015-12-12 Impact factor: 3.052
Authors: Jana Zweerings; Mikhail Zvyagintsev; Bruce I Turetsky; Martin Klasen; Andrea A König; Erik Roecher; Arnim J Gaebler; Klaus Mathiak Journal: Hum Brain Mapp Date: 2019-05-12 Impact factor: 5.038
Authors: Peter Zwanzger; M Zavorotnyy; J Diemer; T Ruland; K Domschke; M Christ; N Michael; B Pfleiderer Journal: J Neural Transm (Vienna) Date: 2012-08-25 Impact factor: 3.575