| Literature DB >> 16288819 |
Ewa Ellis1, Martin Wagner, Frank Lammert, Antal Nemeth, Judith Gumhold, Christian P Strassburg, Christian Kylander, Despina Katsika, Michael Trauner, Curt Einarsson, Hanns-Ulrich Marschall.
Abstract
We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.Entities:
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Year: 2005 PMID： 16288819 DOI： 10.1016/j.jhep.2005.09.011
Source DB: PubMed Journal: J Hepatol ISSN： 0168-8278 Impact factor: 25.083