Literature DB >> 16288524

Deconjugation of dehydroamino acids: stereoselective synthesis of racemic (E)-vinylglycines.

Paul A Alexander1, Stephen P Marsden, Dulce M Muñoz Subtil, John C Reader.   

Abstract

[reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylglycines from aliphatic aldehydes is reported. The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids.

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Year:  2005        PMID: 16288524     DOI: 10.1021/ol052139q

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Asymmetric synthesis of beta,gamma-unsaturated alpha-amino acids via efficient kinetic resolution with cinchona alkaloids.

Authors:  Jianfeng Hang; Li Deng
Journal:  Bioorg Med Chem Lett       Date:  2009-04-05       Impact factor: 2.823

  1 in total

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