Literature DB >> 16287992

Acid acclimation by Helicobacter pylori.

George Sachs1, David L Weeks, Yi Wen, Elizabeth A Marcus, David R Scott, Klaus Melchers.   

Abstract

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.

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Year:  2005        PMID： 16287992     DOI： 10.1152/physiol.00032.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  48 in total

1.  Characterization of Key Helicobacter pylori Regulators Identifies a Role for ArsRS in Biofilm Formation.

Authors:  Stephanie L Servetas; Beth M Carpenter; Kathryn P Haley; Jeremy J Gilbreath; Jennifer A Gaddy; D Scott Merrell
Journal:  J Bacteriol       Date:  2016-08-25       Impact factor: 3.490

2.  Measurement of Internal pH in Helicobacter pylori by Using Green Fluorescent Protein Fluorimetry.

Authors:  Yi Wen; David R Scott; Olga Vagin; Elmira Tokhtaeva; Elizabeth A Marcus; George Sachs
Journal:  J Bacteriol       Date:  2018-06-25       Impact factor: 3.490

3.  The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter.

Authors:  Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
Journal:  J Bacteriol       Date:  2007-01-12       Impact factor: 3.490

4.  A cis-encoded antisense small RNA regulated by the HP0165-HP0166 two-component system controls expression of ureB in Helicobacter pylori.

Authors:  Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
Journal:  J Bacteriol       Date:  2010-10-22       Impact factor: 3.490

5.  The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori.

Authors:  Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
Journal:  J Bacteriol       Date:  2008-10-31       Impact factor: 3.490

6.  The Helicobacter pylori HypA·UreE2 Complex Contains a Novel High-Affinity Ni(II)-Binding Site.

Authors:  Heidi Q Hu; Hsin-Ting Huang; Michael J Maroney
Journal:  Biochemistry       Date:  2018-05-10       Impact factor: 3.162

7.  Chemometric descriptors in modeling the carbonic anhydrase inhibition activity of sulfonamide and sulfamate derivatives.

Authors:  Brij Kishore Sharma; Pradeep Pilania; Kirti Sarbhai; Prithvi Singh; Yenamandra S Prabhakar
Journal:  Mol Divers       Date:  2009-08-06       Impact factor: 2.943

8.  Lactobacillus reuteri 100-23 modulates urea hydrolysis in the murine stomach.

Authors:  Charlotte M Wilson; Diane Loach; Blair Lawley; Tracey Bell; Ian M Sims; Paul W O'Toole; Aldert Zomer; Gerald W Tannock
Journal:  Appl Environ Microbiol       Date:  2014-07-25       Impact factor: 4.792

Review 9.  Targeting of Helicobacter pylori VacA to mitochondria.

Authors:  Antoine Galmiche; Joachim Rassow
Journal:  Gut Microbes       Date:  2010 Nov-Dec

10.  Histidine residue 94 is involved in pH sensing by histidine kinase ArsS of Helicobacter pylori.

Authors:  Stefanie Müller; Monika Götz; Dagmar Beier
Journal:  PLoS One       Date:  2009-09-07       Impact factor: 3.240
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