Literature DB >> 16287987

New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.

Mahin D Maines1.   

Abstract

Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27). These, together with the protein's primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16287987     DOI： 10.1152/physiol.00029.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  53 in total

1.  Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease.

Authors:  Fabio Di Domenico; Gilda Pupo; Cesare Mancuso; Eugenio Barone; Francesca Paolini; Andrea Arena; Carla Blarzino; Frederick A Schmitt; Elizabeth Head; D Allan Butterfield; Marzia Perluigi
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

2.  Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.

Authors:  Matthias Vogel; Michael Lawson; Wolfgang Sippl; Udo Conrad; Werner Roos
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157

3.  Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.

Authors:  Tihomir Miralem; Peter E M Gibbs; Fernando Revert; Juan Saus; Mahin D Maines
Journal:  J Biol Chem       Date:  2010-02-22       Impact factor: 5.157

4.  Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS).

Authors:  Peter E M Gibbs; Tihomir Miralem; Nicole Lerner-Marmarosh; Cicerone Tudor; Mahin D Maines
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

5.  Biliverdin reductase A in the prevention of cellular senescence against oxidative stress.

Authors:  Sung Young Kim; Hyun Tae Kang; Hae Ri Choi; Sang Chul Park
Journal:  Exp Mol Med       Date:  2011-01-31       Impact factor: 8.718

6.  Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt.

Authors:  Rui Zeng; Ying Yao; Min Han; Xiaoqin Zhao; Xiao-Cheng Liu; Juncheng Wei; Yun Luo; Juan Zhang; Jianfeng Zhou; Shixuan Wang; Ding Ma; Gang Xu
Journal:  J Am Soc Nephrol       Date:  2008-01-09       Impact factor: 10.121

7.  Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.

Authors:  Nicole Lerner-Marmarosh; Tihomir Miralem; Peter E M Gibbs; Mahin D Maines
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-07       Impact factor: 11.205

8.  Antioxidant properties of blirubin in the model organism, Caenorhabditis elegans.

Authors:  Danny McCaughan; Catherine Au; Alexandre Benedetto; Dejan Milatovic; Judy Aschner; Michael Aschner
Journal:  Int J Neuroprot Neuroregener       Date:  2008

Review 9.  The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation.

Authors:  Eugenio Barone; Fabio Di Domenico; Cesare Mancuso; D Allan Butterfield
Journal:  Neurobiol Dis       Date:  2013-10-02       Impact factor: 5.996

10.  Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.

Authors:  Li Yi; Paul M Jenkins; Lars I Leichert; Ursula Jakob; Jeffrey R Martens; Stephen W Ragsdale
Journal:  J Biol Chem       Date:  2009-05-27       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.