PURPOSE: To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test. METHODS: Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables. RESULTS: Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness. CONCLUSIONS: Both OCT measurements can detect early retinal damage in NDR patients. Copyright 2005 S. Karger AG, Basel.
PURPOSE: To detect early diabetic damage in type 2 diabetes mellituspatients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test. METHODS: Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables. RESULTS: Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness. CONCLUSIONS: Both OCT measurements can detect early retinal damage in NDR patients. Copyright 2005 S. Karger AG, Basel.
Authors: Donald C Hood; Susan C Anderson; Michael Wall; Ali S Raza; Randy H Kardon Journal: Invest Ophthalmol Vis Sci Date: 2009-05-14 Impact factor: 4.799
Authors: Kevin W Bronson-Castain; Marcus A Bearse; Jessica Neuville; Soffia Jonasdottir; Barbara King-Hooper; Shirin Barez; Marilyn E Schneck; Anthony J Adams Journal: Retina Date: 2009-05 Impact factor: 4.256