BACKGROUND: Cetuximab is a member of a new family of antineoplastic agents that inhibit epidermal growth factor receptor (EGFR). These molecules may induce acneiform eruptions. In this study, we aimed at evaluating (a) the characteristics of acne and (b) whether these acneiform eruptions could be improved by classical anti-acne treatments. METHODS: All patients treated with cetuximab in a single institution from October 2003 to May 2004 were prospectively evaluated. The presence of acne, its severity, need for a treatment and response to this treatment were recorded. RESULTS: 13 patients were included: 11 (85%) developed acneiform eruptions after a mean interval of 10 days. It was severe in 4/13 (31%). Comedones were never found and acne involved nonclassical sites in 3/11. Antibiotic treatment was given to 4 and local treatment to 2 patients: it was always efficient. CONCLUSION: Cetuximab-induced acne is frequent, differs from classical acne and may be treated effectively with classical modalities. Copyright 2005 S. Karger AG, Basel.
BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit epidermal growth factor receptor (EGFR). These molecules may induce acneiform eruptions. In this study, we aimed at evaluating (a) the characteristics of acne and (b) whether these acneiform eruptions could be improved by classical anti-acne treatments. METHODS: All patients treated with cetuximab in a single institution from October 2003 to May 2004 were prospectively evaluated. The presence of acne, its severity, need for a treatment and response to this treatment were recorded. RESULTS: 13 patients were included: 11 (85%) developed acneiform eruptions after a mean interval of 10 days. It was severe in 4/13 (31%). Comedones were never found and acne involved nonclassical sites in 3/11. Antibiotic treatment was given to 4 and local treatment to 2 patients: it was always efficient. CONCLUSION:Cetuximab-induced acne is frequent, differs from classical acne and may be treated effectively with classical modalities. Copyright 2005 S. Karger AG, Basel.
Authors: Z Reguiai; J B Bachet; C Bachmeyer; L Peuvrel; M Beylot-Barry; M Bezier; E Boucher; C Chevelle; P Colin; R Guimbaud; L Mineur; M A Richard; P Artru; P Dufour; J M Gornet; E Samalin; R J Bensadoun; M Ychou; T André; B Dreno; O Bouché Journal: Support Care Cancer Date: 2012-04-27 Impact factor: 3.603
Authors: Weon Ju Lee; Seong Geun Chi; Dong Jae Park; Jun Young Kim; Ho Youn Kim; Seok-Jong Lee; Do Won Kim; Moon Kyu Kim; Jung Chul Kim; Mi Woo Lee Journal: Ann Dermatol Date: 2011-02-28 Impact factor: 1.444
Authors: Nannie Bangsgaard; Mischa Houtkamp; Danita H Schuurhuis; Paul W H I Parren; Ole Baadsgaard; Hans W M Niessen; Lone Skov Journal: PLoS One Date: 2012-06-25 Impact factor: 3.240