OBJECTIVE: The authors examined the relationship between impaired insight regarding cognitive and functional deficits and frontal cortex hypometabolism in 41 patients with Alzheimer disease (AD). METHODS: Regional cerebral glucose metabolism was determined with (18F)fluorodeoxyglucose and positron emission tomography. Level of insight was measured with the clinician-rated Neurobehavioral Rating Scale, and severity of global cognitive impairment was determined with the Mini-Mental State Exam. RESULTS: Inaccurate insight was correlated with glucose metabolic rate in the right lateral frontal cortex (Brodmann areas 6 and 45, and the lateral aspect of Brodmann areas 8 and 9) after controlling for global cognitive dysfunction. CONCLUSIONS: The findings from this study help to further elucidate the neurobiological mechanisms underlying impaired insight in AD, indicating a link between this important clinical phenomenon and dysmetabolism in a focal region of the right prefrontal cortex.
OBJECTIVE: The authors examined the relationship between impaired insight regarding cognitive and functional deficits and frontal cortex hypometabolism in 41 patients with Alzheimer disease (AD). METHODS: Regional cerebral glucose metabolism was determined with (18F)fluorodeoxyglucose and positron emission tomography. Level of insight was measured with the clinician-rated Neurobehavioral Rating Scale, and severity of global cognitive impairment was determined with the Mini-Mental State Exam. RESULTS: Inaccurate insight was correlated with glucose metabolic rate in the right lateral frontal cortex (Brodmann areas 6 and 45, and the lateral aspect of Brodmann areas 8 and 9) after controlling for global cognitive dysfunction. CONCLUSIONS: The findings from this study help to further elucidate the neurobiological mechanisms underlying impaired insight in AD, indicating a link between this important clinical phenomenon and dysmetabolism in a focal region of the right prefrontal cortex.
Authors: David L Sultzer; Lorraine P Leskin; Rebecca J Melrose; Dylan G Harwood; Theresa A Narvaez; Timothy K Ando; Mark A Mandelkern Journal: Am J Geriatr Psychiatry Date: 2013-09-08 Impact factor: 4.105
Authors: Winnie Qian; Tom A Schweizer; Nathan W Churchill; Colleen Millikin; Zahinoor Ismail; Eric E Smith; Lisa M Lix; David G Munoz; Joseph J Barfett; Tarek K Rajji; Corinne E Fischer Journal: Am J Geriatr Psychiatry Date: 2018-10-02 Impact factor: 4.105
Authors: Siobhán Harty; Ian H Robertson; Carlo Miniussi; Owen C Sheehy; Ciara A Devine; Sarahjane McCreery; Redmond G O'Connell Journal: J Neurosci Date: 2014-03-05 Impact factor: 6.167
Authors: Michele L Ries; Britta M Jabbar; Taylor W Schmitz; Mehul A Trivedi; Carey E Gleason; Cynthia M Carlsson; Howard A Rowley; Sanjay Asthana; Sterling C Johnson Journal: J Int Neuropsychol Soc Date: 2007-05 Impact factor: 2.892