PRIMARY OBJECTIVE: To evaluate the process of bone metabolism after traumatic brain injury. RESEARCH DESIGN: Randomized controlled trial. METHODS AND PROCEDURES: Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively. MAIN OUTCOMES AND RESULTS: There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044). CONCLUSIONS: This finding suggests that brain injury could induce osteoporosis by immobilization.
PRIMARY OBJECTIVE: To evaluate the process of bone metabolism after traumatic brain injury. RESEARCH DESIGN: Randomized controlled trial. METHODS AND PROCEDURES: Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively. MAIN OUTCOMES AND RESULTS: There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044). CONCLUSIONS: This finding suggests that brain injury could induce osteoporosis by immobilization.
Authors: Karen N Borschmann; Sarah S Rewell; Sandra Iuliano; Ali Ghasem-Zadeh; Rachel A Davey; Heidi Ho; Peta N Skeers; Julie Bernhardt; David W Howells Journal: PLoS One Date: 2017-03-09 Impact factor: 3.240
Authors: R D Brady; B L Grills; T Romano; J D Wark; T J O'Brien; S R Shultz; S J McDonald Journal: J Musculoskelet Neuronal Interact Date: 2016-12-14 Impact factor: 2.041
Authors: Quante Singleton; Kumar Vaibhav; Molly Braun; Chandani Patel; Andrew Khayrullin; Bharati Mendhe; Byung R Lee; Ravindra Kolhe; Helen Kaiser; Mohamed E Awad; Tunde Fariyike; Ranya Elsayed; Mohammed Elsalanty; Carlos M Isales; Yutao Liu; Mark W Hamrick; Krishnan M Dhandapani; Sadanand Fulzele Journal: Cells Date: 2019-01-17 Impact factor: 6.600