| Literature DB >> 16286053 |
Eva Poveda1, Berta Rodés, Sophie Lebel-Binay, Jean-Louis Faudon, Victoria Jimenez, Vincent Soriano.
Abstract
Enfuvirtide (ENF) is the first of a novel class of drugs that blocks HIV fusion to host cells. We analyzed the dynamics of genotypic and phenotypic resistance to ENF during and after long-term ENF therapy and its clinical implications in eight heavily treatment-experienced HIV-infected patients who underwent salvage therapy with enfuvirtide along with other antiretroviral agents. All patients showed a rapid decline in plasma HIV-RNA followed by viral rebound. Changes at codons 36, 42, 43 and/or 44 within the HR1 region of gp41 were selected in all cases, resulting in high-level phenotypic resistance to ENF, ranging from 15- to 445-fold. Both genotypic and phenotypic resistance to ENF rapidly disappeared after discontinuation of the drug, suggesting that ENF-resistant viruses may have an impaired replicative capacity.Entities:
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Year: 2005 PMID： 16286053 DOI： 10.1016/j.jcv.2005.02.004
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168