| Literature DB >> 16286013 |
Abstract
Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.Entities:
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Year: 2005 PMID： 16286013 DOI： 10.1016/j.immuni.2005.10.004
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745