| Literature DB >> 16284272 |
Gerhard A Blab, Laurent Cognet, Stéphane Berciaud, Isabelle Alexandre, Dieter Husar, José Remacle, Brahim Lounis.
Abstract
We present a novel readout scheme for gold nanoparticle-based DNA microarrays relying on "Laser-Induced Scattering around a NanoAbsorber". It provides direct counting of individual nanoparticles present on each array spot and stable signals, without any silver enhancement. Given the detection of nanometer-sized particles, which minimize the steric hindrance, the linear dynamic range of the method is particularly large and well suited for microarray detection.Mesh:
Substances:
Year: 2005 PMID: 16284272 PMCID: PMC1367045 DOI: 10.1529/biophysj.105.076182
Source DB: PubMed Journal: Biophys J ISSN: 0006-3495 Impact factor: 4.033