Literature DB >> 16282947

Safety and immunogenicity of palivizumab (Synagis) administered for two seasons.

Donald Null1, Bernard Pollara, Penelope H Dennehy, Jean Steichen, Pablo J Sánchez, Laurence B Givner, David Carlin, Bernard Landry, Franklin H Top, Edward Connor.   

Abstract

To evaluate the safety and immunogenicity of palivizumab, 55 children who received palivizumab in the IMpact-RSV trial received 5 monthly doses of 15 mg/kg palivizumab (Synagis) during the subsequent year. The single child with an antipalivizumab titer of >1/40 had no associated serious adverse events and had expected serum palivizumab trough concentrations. Second year palivizumab prophylaxis was safe and well-tolerated.

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Year:  2005        PMID: 16282947     DOI: 10.1097/01.inf.0000183938.33484.bd

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN: 0891-3668            Impact factor:   2.129


  18 in total

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