BACKGROUND: Regular exercise has been reported to slow the age-associated declines in natural killer cell activity (NKCA). To evaluate this response, we recruited older, postmenopausal women (65-85 years old) to fill one of two groups: training (10 weeks of resistance exercise; TR) or control. METHODS: Blood samples were collected from an arm vein in the TR group at rest (PRE), immediately following (POST), and 2 hours (2H) following an acute bout of resistance exercise both before (BEFORE) and after (AFTER) training. Leukocytes and NKCA were determined by flow cytometry and a whole blood (51)Cr release assay, respectively. RESULTS: Acute exercise increased total leukocyte (p < .05), CD8 (p < .05), CD4 (p < .05), and CD56 counts (p < .05), but there was no effect of training. NKCA was greater TR-AFTER-PRE (136%), -POST (80%), and -2H (127%) compared to similar values from TR-BEFORE (p < .05). CONCLUSION: Increased resting NKCA after chronic resistance training suggests that immunity has been improved.
BACKGROUND: Regular exercise has been reported to slow the age-associated declines in natural killer cell activity (NKCA). To evaluate this response, we recruited older, postmenopausal women (65-85 years old) to fill one of two groups: training (10 weeks of resistance exercise; TR) or control. METHODS: Blood samples were collected from an arm vein in the TR group at rest (PRE), immediately following (POST), and 2 hours (2H) following an acute bout of resistance exercise both before (BEFORE) and after (AFTER) training. Leukocytes and NKCA were determined by flow cytometry and a whole blood (51)Cr release assay, respectively. RESULTS: Acute exercise increased total leukocyte (p < .05), CD8 (p < .05), CD4 (p < .05), and CD56 counts (p < .05), but there was no effect of training. NKCA was greater TR-AFTER-PRE (136%), -POST (80%), and -2H (127%) compared to similar values from TR-BEFORE (p < .05). CONCLUSION: Increased resting NKCA after chronic resistance training suggests that immunity has been improved.
Authors: Juha J Hulmi; T Myllymäki; M Tenhumäki; N Mutanen; R Puurtinen; G Paulsen; A A Mero Journal: Eur J Appl Physiol Date: 2010-01-26 Impact factor: 3.078
Authors: C D Schwindt; F Zaldivar; L Wilson; S-Y Leu; J Wang-Rodriguez; P J Mills; D M Cooper Journal: Br J Sports Med Date: 2006-10-04 Impact factor: 13.800
Authors: Brian K McFarlin; Adam S Venable; Andrea L Henning; Jill N Best Sampson; Kathryn Pennel; Jakob L Vingren; David W Hill Journal: BBA Clin Date: 2016-02-18