Literature DB >> 16281938

Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation.

Aleksandar Radonić1, Olivia Oswald, Stefanie Thulke, Nina Brockhaus, Andreas Nitsche, Wolfgang Siegert, Johannes Schetelig.   

Abstract

The clinical significance of human herpesvirus (HHV-6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV-6 variants A and B. Platelet engraftment was delayed in patients with HHV-6B infections but not with HHV-6A infections detected before day +28. In multivariate analysis early HHV-6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV-6 should be studied separately; early infections with HHV-6B may contribute to delayed platelet engraftment after allogeneic SCT.

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Year:  2005        PMID： 16281938     DOI： 10.1111/j.1365-2141.2005.05788.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  5 in total

1.  Human herpesvirus 6 infection after hematopoietic cell transplantation: is routine surveillance necessary?

Authors:  Brian C Betts; Jo-Anne H Young; Celalettin Ustun; Qing Cao; Daniel J Weisdorf
Journal:  Biol Blood Marrow Transplant       Date:  2011-04-20       Impact factor: 5.742

2.  Frequent human herpesvirus-6 viremia but low incidence of encephalitis in double-unit cord blood recipients transplanted without antithymocyte globulin.

Authors:  Amanda L Olson; Parastoo B Dahi; Junting Zheng; Sean M Devlin; Marissa Lubin; Anne Marie Gonzales; Sergio A Giralt; Miguel-Angel Perales; Esperanza B Papadopoulos; Doris M Ponce; James W Young; Nancy A Kernan; Andromachi Scaradavou; Richard J O'Reilly; Trudy N Small; Genovefa Papanicolaou; Juliet N Barker
Journal:  Biol Blood Marrow Transplant       Date:  2014-02-16       Impact factor: 5.742

3.  Quantitative expression analysis of HHV-6 cell receptor CD46 on cells of human cord blood, peripheral blood and G-CSF mobilised leukapheresis cells.

Authors:  Stefanie Thulke; Aleksandar Radonić; Andreas Nitsche; Wolfgang Siegert
Journal:  Virol J       Date:  2006-09-19       Impact factor: 4.099

4.  Prophylactic Foscarnet for Human Herpesvirus 6: Effect on Hematopoietic Engraftment after Reduced-Intensity Conditioning Umbilical Cord Blood Transplantation.

Authors:  Najla El Jurdi; John Rogosheske; Todd DeFor; Nelli Bejanyan; Mukta Arora; Veronika Bachanova; Brian Betts; Fiona He; Shernan Holtan; Murali Janakiram; Samantha Larson; Joseph Maakaron; Armin Rashidi; Erica Warlick; John E Wagner; Jo-Anne H Young; Daniel Weisdorf; Claudio G Brunstein
Journal:  Transplant Cell Ther       Date:  2020-10-11

5.  Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Authors:  Tuan L Phan; Kristen Carlin; Per Ljungman; Ioannis Politikos; Vicki Boussiotis; Michael Boeckh; Michele L Shaffer; Danielle M Zerr
Journal:  Biol Blood Marrow Transplant       Date:  2018-04-21       Impact factor: 5.742
  5 in total

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