Literature DB >> 1628139

MK801 attenuates behavioural adaptation to chronic nicotine administration in rats.

M Shoaib1, I P Stolerman.   

Abstract

The effect of administering MK801 (0.3 mg kg-1) during chronic nicotine (0.4 mg kg-1) treatment was studied on locomotor activity in rats. Sensitization of the locomotor activity response to nicotine was seen with chronic nicotine treatment. This sensitization was attenuated in rats that had received MK801 30 min before the daily nicotine injections during chronic treatment. These results suggest that the NMDA receptor may be involved in the adaptive processes seen with chronic nicotine administration.

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Year:  1992        PMID： 1628139      PMCID： PMC1908456          DOI： 10.1111/j.1476-5381.1992.tb09010.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


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