Literature DB >> 16281311

Synthesis and antiviral evaluation of novel exomethylene acyclic nucleosides and phosphonic acid nucleosides.

Aihong Kim1, Joon Hee Hong.   

Abstract

This paper describes a very simple synthesis route of novel acyclic nucleosides and phosphonic acid nucleosides. The condensation of the mesylates 6 and 17 with the natural nucleosidic bases (A, C, U, T) under nucleophilic substitution (K(2)CO(3), 18-Crown-6, DMF) and deprotection afforded the target nucleosides (11, 12, 13, 14) and phosphonic acid nucleosides (22, 23, 24, 25). In addition, these compounds were evaluated for their antiviral properties against various viruses. Uracil derivative 24 shows significant anti-HCMV activity (EC(50) = 10.24 microM).

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Year:  2005        PMID： 16281311     DOI： 10.1002/ardp.200500187

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  2 in total

1.  Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.

Authors:  Shuhei Imoto; Satoru Kohgo; Ryoh Tokuda; Hiroki Kumamoto; Manabu Aoki; Masayuki Amano; Nobuyo Kuwata-Higashi; Hiroaki Mitsuya; Kazuhiro Haraguchi
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2015       Impact factor: 1.381

2.  Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.

Authors:  Mariola Koszytkowska-Stawińska; Erik De Clercq; Jan Balzarini
Journal:  Bioorg Med Chem       Date:  2009-05-03       Impact factor: 3.641
  2 in total

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