S Goya Wannamethee1, A Gerald Shaper, Peter H Whincup. 1. Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom. goya@pcps.ucl.ac.uk
Abstract
BACKGROUND: Most population studies have reported weak or nonsignificant associations between body mass index (BMI; in kg/m2) and lung function. OBJECTIVE: This study focused on the distinct effects of fat distribution and body composition on lung function and examined these relations in elderly men. DESIGN: The study was a cross-sectional evaluation of 2744 men aged 60-79 y who were free of cardiovascular disease and cancer and were drawn from general practices in 24 British towns. Anthropometric and body-composition [including fat mass (FM), fat-free mass (FFM), and percentage body fat (%BF) evaluated with bioelectric impedance] measurements were made, and lung function was examined by using spirometry. RESULTS: Height-standardized forced expiratory volume in 1 s (FEV1) was diminished only in lean (BMI < 22.5) and obese (BMI > or = 30) men, but forced vital capacity (FVC) tended to decrease with increasing BMI (P < 0.01). All other measures of adiposity [ie, waist circumference (WC), waist-hip ratio (WHR), FM, and %BF] were significantly and inversely related to FEV1 and FVC after adjustment for confounders, including age and cigarette smoking (all: P < 0.05). This was seen both in nonobese (BMI < 30) and obese men. FFM was positively associated with FEV1 (P = 0.03) and to a lesser extent with FVC. Higher BMI and FFM were both associated with reduced odds of a low FEV1-FVC ratio (ie, <70%). CONCLUSION: Total body fat and central adiposity are inversely associated with lung function, but increased FFM reflecting increases in muscle mass is associated with increased lung function and lower odds of low FEV1:FVC in the elderly.
BACKGROUND: Most population studies have reported weak or nonsignificant associations between body mass index (BMI; in kg/m2) and lung function. OBJECTIVE: This study focused on the distinct effects of fat distribution and body composition on lung function and examined these relations in elderly men. DESIGN: The study was a cross-sectional evaluation of 2744 men aged 60-79 y who were free of cardiovascular disease and cancer and were drawn from general practices in 24 British towns. Anthropometric and body-composition [including fat mass (FM), fat-free mass (FFM), and percentage body fat (%BF) evaluated with bioelectric impedance] measurements were made, and lung function was examined by using spirometry. RESULTS: Height-standardized forced expiratory volume in 1 s (FEV1) was diminished only in lean (BMI < 22.5) and obese (BMI > or = 30) men, but forced vital capacity (FVC) tended to decrease with increasing BMI (P < 0.01). All other measures of adiposity [ie, waist circumference (WC), waist-hip ratio (WHR), FM, and %BF] were significantly and inversely related to FEV1 and FVC after adjustment for confounders, including age and cigarette smoking (all: P < 0.05). This was seen both in nonobese (BMI < 30) and obesemen. FFM was positively associated with FEV1 (P = 0.03) and to a lesser extent with FVC. Higher BMI and FFM were both associated with reduced odds of a low FEV1-FVC ratio (ie, <70%). CONCLUSION: Total body fat and central adiposity are inversely associated with lung function, but increased FFM reflecting increases in muscle mass is associated with increased lung function and lower odds of low FEV1:FVC in the elderly.
Authors: Andrea P Rossi; Nora L Watson; Anne B Newman; Tamara B Harris; Stephen B Kritchevsky; Douglas C Bauer; Suzanne Satterfield; Bret H Goodpaster; Mauro Zamboni Journal: J Gerontol A Biol Sci Med Sci Date: 2011-04-15 Impact factor: 6.053
Authors: Yong Liu; Roy A Pleasants; Janet B Croft; Njira Lugogo; Jill Ohar; Khosrow Heidari; Charlie Strange; Anne G Wheaton; David M Mannino; Monica Kraft Journal: Respir Med Date: 2015-05-16 Impact factor: 3.415
Authors: Talea Cornelius; Joseph E Schwartz; Pallavi Balte; Surya P Bhatt; Patricia A Cassano; David Currow; David R Jacobs; Miriam Johnson; Ravi Kalhan; Richard Kronmal; Laura Loehr; George T O'Connor; Benjamin Smith; Wendy B White; Sachin Yende; Elizabeth C Oelsner Journal: Am J Epidemiol Date: 2020-10-01 Impact factor: 4.897
Authors: Earle C Chambers; Stanley Heshka; Lisl Y Huffaker; Yer Xiong; Jack Wang; Edward Eden; Dympna Gallagher; F Xavier Pi-Sunyer Journal: Lung Date: 2007-10-19 Impact factor: 2.584
Authors: Elina Seppänen-Nuijten; Marjaana Lahti-Koski; Satu Männistö; Paul Knekt; Harri Rissanen; Arpo Aromaa; Markku Heliövaara Journal: BMC Public Health Date: 2009-12-04 Impact factor: 3.295