Literature DB >> 162802

Collagenase in the treatment of dermal and decubitus ulcers.

D B Rao, P G Sane, E L Georgiev.   

Abstract

The current management of decubitus ulcers, factors in wound healing and the role of enzymes in treatment are discussed. The therapeutic benefits of collagenase (Santyl) ointment in 21 patients are described, supplemented by serial color photographs. Statistical evidence is provided for the conclusion that collagenase ointment is an excellent adjunct to therapy.

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Year:  1975        PMID： 162802     DOI： 10.1111/j.1532-5415.1975.tb00376.x

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN： 0002-8614            Impact factor:   5.562


  10 in total

1.  Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration.

Authors:  Lei Shi; Ryan Ermis; Anastacia Garcia; Dale Telgenhoff; Duncan Aust
Journal:  Int Wound J       Date:  2010-04       Impact factor: 3.315

2.  The cost of wound debridement: a Canadian perspective.

Authors:  Kevin Y Woo; David Keast; Nancy Parsons; R Gary Sibbald; Nicole Mittmann
Journal:  Int Wound J       Date:  2013-07-09       Impact factor: 3.315

3.  Treatment of dermal and decubitus ulcers.

Authors:  M M Nierman
Journal:  Drugs       Date:  1978-03       Impact factor: 9.546

Review 4.  Diversity, Structures, and Collagen-Degrading Mechanisms of Bacterial Collagenolytic Proteases.

Authors:  Yu-Zhong Zhang; Li-Yuan Ran; Chun-Yang Li; Xiu-Lan Chen
Journal:  Appl Environ Microbiol       Date:  2015-07-06       Impact factor: 4.792

5.  Collagenase-assisted wound bed preparation: An in vitro comparison between Vibrio alginolyticus and Clostridium histolyticum collagenases on substrate specificity.

Authors:  Roberta Di Pasquale; Susanna Vaccaro; Michele Caputo; Christian Cuppari; Salvatore Caruso; Angela Catania; Luciano Messina
Journal:  Int Wound J       Date:  2019-05-31       Impact factor: 3.315

6.  A new formulation of collagenase ointment (iruxol((r)) mono) in the treatment of ulcers of the lower extremities: a randomised, placebo-controlled, double-blind study.

Authors:  B Palmieri; M Magri
Journal:  Clin Drug Investig       Date:  1998       Impact factor: 2.859

7.  Collagenase promotes the cellular responses to injury and wound healing in vivo.

Authors:  Kathleen N Riley; Ira M Herman
Journal:  J Burns Wounds       Date:  2005-05-17

8.  Vibrio Proteases for Biomedical Applications: Modulating the Proteolytic Secretome of V. alginolyticus and V. parahaemolyticus for Improved Enzymes Production.

Authors:  Monica Salamone; Aldo Nicosia; Giulio Ghersi; Marcello Tagliavia
Journal:  Microorganisms       Date:  2019-09-24

Review 9.  Wound debridement products and techniques: clinical examples and literature review.

Authors:  Marcela Nowak; Dorota Mehrholz; Wioletta Barańska-Rybak; Roman J Nowicki
Journal:  Postepy Dermatol Alergol       Date:  2022-07-14       Impact factor: 1.664

10.  Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation.

Authors:  Amitava Das; Soma Datta; Eric Roche; Scott Chaffee; Elizabeth Jose; Lei Shi; Komel Grover; Savita Khanna; Chandan K Sen; Sashwati Roy
Journal:  Sci Rep       Date:  2018-01-26       Impact factor: 4.379
  10 in total

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