| Literature DB >> 16278862 |
Scott Smemo1, Petra Nowotny, Anthony L Hinrichs, John S K Kauwe, Sara Cherny, Katherine Erickson, Amanda J Myers, Mona Kaleem, Lauren Marlowe, Alison M Gibson, Paul Hollingworth, Michael C O'Donovan, Chris M Morris, Peter Holmans, Simon Lovestone, John C Morris, Leon Thal, Yonghong Li, Andrew Grupe, John Hardy, Michael J Owen, Julie Williams, Alison Goate.
Abstract
Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.Entities:
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Year: 2006 PMID： 16278862 DOI： 10.1002/ana.20673
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422