OBJECTIVE: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. METHODS: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. RESULTS: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. INTERPRETATION: These rates provide a benchmark that can be used to monitor future treatment response in PSP.
OBJECTIVE: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. METHODS: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. RESULTS:Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. INTERPRETATION: These rates provide a benchmark that can be used to monitor future treatment response in PSP.
Authors: Jennifer L Whitwell; Jia Xu; Jay N Mandrekar; Jeffrey L Gunter; Clifford R Jack; Keith A Josephs Journal: Parkinsonism Relat Disord Date: 2011-11-13 Impact factor: 4.891
Authors: Graeme C Schwindt; Naida L Graham; Elizabeth Rochon; David F Tang-Wai; Nancy J Lobaugh; Tiffany W Chow; Sandra E Black Journal: Hum Brain Mapp Date: 2011-11-23 Impact factor: 5.038
Authors: Richard M Tsai; Iryna Lobach; Jee Bang; Jennifer L Whitwell; Matthew L Senjem; Clifford R Jack; Howard Rosen; Bruce Miller; Adam L Boxer Journal: Parkinsonism Relat Disord Date: 2016-04-24 Impact factor: 4.891
Authors: Jerzy Slowinski; Akiko Imamura; Ryan J Uitti; Robert A Pooley; Audrey J Strongosky; Dennis W Dickson; Daniel F Broderick; Zbigniew K Wszolek Journal: J Neurol Date: 2007-12-19 Impact factor: 4.849
Authors: Jennifer L Whitwell; Clifford R Jack; Joseph E Parisi; David S Knopman; Bradley F Boeve; Ronald C Petersen; Tanis J Ferman; Dennis W Dickson; Keith A Josephs Journal: Brain Date: 2007-03-08 Impact factor: 13.501
Authors: Jennifer L Whitwell; Günter U Höglinger; Angelo Antonini; Yvette Bordelon; Adam L Boxer; Carlo Colosimo; Thilo van Eimeren; Lawrence I Golbe; Jan Kassubek; Carolin Kurz; Irene Litvan; Alexander Pantelyat; Gil Rabinovici; Gesine Respondek; Axel Rominger; James B Rowe; Maria Stamelou; Keith A Josephs Journal: Mov Disord Date: 2017-05-13 Impact factor: 10.338
Authors: Melissa E Murray; Naomi Kouri; Wen-Lang Lin; Clifford R Jack; Dennis W Dickson; Prashanthi Vemuri Journal: Alzheimers Res Ther Date: 2014-01-02 Impact factor: 6.982
Authors: Shubir Dutt; Richard J Binney; Hilary W Heuer; Phi Luong; Suneth Attygalle; Priyanka Bhatt; Gabe A Marx; Jonathan Elofson; Maria C Tartaglia; Irene Litvan; Scott M McGinnis; Bradford C Dickerson; John Kornak; Dana Waltzman; Lisa Voltarelli; Norbert Schuff; Gil D Rabinovici; Joel H Kramer; Clifford R Jack; Bruce L Miller; Howard J Rosen; Adam L Boxer Journal: Neurology Date: 2016-10-14 Impact factor: 9.910