Man-lin Zhao1, Yu-kun Feng, Wen-jin Qi. 1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
Abstract
OBJECTIVE: To investigate correlation between part of histocompatibility leukocyte antigen (HLA) class II gene and gestational diabetes mellitus (GDM). METHODS: Part of HLA-II gene was examined by polymerase chain reaction sequence specific primer (PCR-SSP). Forty-eight GDM women were served as study group, and forty-eight normal pregnant women were selected as control group. RESULTS: The frequencies of DRB1*0301, DRB1*1302 and DQA1*0301 of GDM (18.8%, 45.8% and 64.6%) in study group were significantly increased compared with control group (4.2%, 18.8% and 41.7%) (P < 0.05). CONCLUSIONS: The results suggest that there is correlation between HLA class II gene and gestational diabetes mellitus. DRB1*0301, DRB1*1302 and DQA1*0301 are the susceptible alleles of GDM.
OBJECTIVE: To investigate correlation between part of histocompatibility leukocyte antigen (HLA) class II gene and gestational diabetes mellitus (GDM). METHODS: Part of HLA-II gene was examined by polymerase chain reaction sequence specific primer (PCR-SSP). Forty-eight GDM women were served as study group, and forty-eight normal pregnant women were selected as control group. RESULTS: The frequencies of DRB1*0301, DRB1*1302 and DQA1*0301 of GDM (18.8%, 45.8% and 64.6%) in study group were significantly increased compared with control group (4.2%, 18.8% and 41.7%) (P < 0.05). CONCLUSIONS: The results suggest that there is correlation between HLA class II gene and gestational diabetes mellitus. DRB1*0301, DRB1*1302 and DQA1*0301 are the susceptible alleles of GDM.