| Literature DB >> 16276351 |
J K J Diss1, D J Faulkes, M M Walker, A Patel, C S Foster, V Budhram-Mahadeo, M B A Djamgoz, D S Latchman.
Abstract
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.Entities:
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Year: 2006 PMID： 16276351 DOI： 10.1038/sj.pcan.4500837
Source DB: PubMed Journal: Prostate Cancer Prostatic Dis ISSN： 1365-7852 Impact factor: 5.554