Literature DB >> 16275971

Troponin: the biomarker of choice for the detection of cardiac injury.

Luciano Babuin1, Allan S Jaffe.   

Abstract

It has been known for 50 years that transaminase activity increases in patients with acute myocardial infarction. With the development of creatine kinase (CK), biomarkers of cardiac injury began to take a major role in the diagnosis and management of patients with acute cardiovascular disease. In 2000 the European Society of Cardiology and the American College of Cardiology recognized the pivotal role of biomarkers and made elevations in their levels the "cornerstone" of diagnosis of acute myocardial infarction. At that time, they also acknowledged that cardiac troponin I and T had supplanted CK-MB as the analytes of choice for diagnosis. In this review, we discuss the science underlying the use of troponin biomarkers, how to interpret troponin values properly and how to apply these measurements to patients who present with possible cardiovascular disease.

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Year:  2005        PMID： 16275971      PMCID： PMC1277047          DOI： 10.1503/cmaj/051291

Source DB:  PubMed          Journal:  CMAJ        ISSN： 0820-3946            Impact factor:   8.262


  193 in total

1.  Renal elimination of troponin T and troponin I.

Authors:  Reinhard Ziebig; Andreas Lun; Berthold Hocher; Friedrich Priem; Claudia Altermann; Gernot Asmus; Hartmut Kern; Rolfdieter Krause; Babette Lorenz; Rainer Möbes; Pranav Sinha
Journal:  Clin Chem       Date:  2003-07       Impact factor: 8.327

2.  Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form.

Authors:  Soichi Takeda; Atsuko Yamashita; Kayo Maeda; Yuichiro Maéda
Journal:  Nature       Date:  2003-07-03       Impact factor: 49.962

3.  Troponin-I elevation in patients with increased left ventricular mass.

Authors:  Shadi M Hamwi; Arvind K Sharma; Neil J Weissman; Steven A Goldstein; Sue Apple; Daniel A Caños; Ellen E Pinnow; Joseph Lindsay
Journal:  Am J Cardiol       Date:  2003-07-01       Impact factor: 2.778

4.  Alternative splicing generates variants in important functional domains of human slow skeletal troponin T.

Authors:  R Gahlmann; A B Troutt; R P Wade; P Gunning; L Kedes
Journal:  J Biol Chem       Date:  1987-11-25       Impact factor: 5.157

5.  Troponin I switching in the developing heart.

Authors:  L Saggin; L Gorza; S Ausoni; S Schiaffino
Journal:  J Biol Chem       Date:  1989-09-25       Impact factor: 5.157

6.  Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes.

Authors:  Peter Ammann; Marco Maggiorini; Osmund Bertel; Edgar Haenseler; Helen I Joller-Jemelka; Erwin Oechslin; Elisabeth I Minder; Hans Rickli; Thomas Fehr
Journal:  J Am Coll Cardiol       Date:  2003-06-04       Impact factor: 24.094

7.  Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis.

Authors:  Christopher deFilippi; Steven Wasserman; Salvatore Rosanio; Eric Tiblier; Heidi Sperger; Monica Tocchi; Robert Christenson; Barry Uretsky; Mathew Smiley; Judith Gold; Henry Muniz; John Badalamenti; Charles Herzog; William Henrich
Journal:  JAMA       Date:  2003-07-16       Impact factor: 56.272

8.  Survival in patients with primary systemic amyloidosis and raised serum cardiac troponins.

Authors:  Angela Dispenzieri; Robert A Kyle; Morie A Gertz; Terry M Therneau; Wayne L Miller; Krishnaswamy Chandrasekaran; Joseph P McConnell; Mary F Burritt; Allan S Jaffe
Journal:  Lancet       Date:  2003-05-24       Impact factor: 79.321

9.  Acute right ventricular infarction secondary to massive pulmonary embolism.

Authors:  I Coma-Canella; C Gamallo; P Martinez Onsurbe; J Lopez-Sendon
Journal:  Eur Heart J       Date:  1988-05       Impact factor: 29.983

10.  Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension.

Authors:  Adam Torbicki; Marcin Kurzyna; Paweł Kuca; Anna Fijałkowska; Jarosław Sikora; Michał Florczyk; Piotr Pruszczyk; Janusz Burakowski; Lilianna Wawrzyńska
Journal:  Circulation       Date:  2003-08-04       Impact factor: 29.690
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  145 in total

1.  Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T.

Authors:  Jiang Zhang; Han Zhang; Serife Ayaz-Guner; Yi-Chen Chen; Xintong Dong; Qingge Xu; Ying Ge
Journal:  Biochemistry       Date:  2011-06-15       Impact factor: 3.162

2.  Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresis.

Authors:  Danny Bottenus; Mohammad Robiul Hossan; Yexin Ouyang; Wen-Ji Dong; Prashanta Dutta; Cornelius F Ivory
Journal:  Lab Chip       Date:  2011-09-21       Impact factor: 6.799

3.  A review of troponins in ischemic heart disease and other conditions.

Authors:  Nedaa Skeik; Deevia Chandrakant Patel
Journal:  Int J Angiol       Date:  2007

4.  Rapid isolation of blood plasma using a cascaded inertial microfluidic device.

Authors:  M Robinson; H Marks; T Hinsdale; K Maitland; G Coté
Journal:  Biomicrofluidics       Date:  2017-03-24       Impact factor: 2.800

5.  Inverse Association between Cardiac Troponin-I and Soluble Receptor for Advanced Glycation End Products in Patients with Non-ST-Segment Elevation Myocardial Infarction.

Authors:  Erick D McNair; Calvin R Wells; A M Qureshi; Colin Pearce; Gudrun Caspar-Bell; Kailash Prasad
Journal:  Int J Angiol       Date:  2011-03

6.  Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure.

Authors:  Jiang Zhang; Moltu J Guy; Holly S Norman; Yi-Chen Chen; Qingge Xu; Xintong Dong; Huseyin Guner; Sijian Wang; Takushi Kohmoto; Ken H Young; Richard L Moss; Ying Ge
Journal:  J Proteome Res       Date:  2011-07-28       Impact factor: 4.466

Review 7.  Perspective on the clinical application of troponin in heart failure and states of cardiac injury.

Authors:  Almasa Bass; J Herbert Patterson; Kirkwood F Adams
Journal:  Heart Fail Rev       Date:  2009-04-05       Impact factor: 4.214

Review 8.  Biomarker guided therapy for heart failure: focus on natriuretic peptides.

Authors:  Kirkwood F Adams; G Michael Felker; Ghassan Fraij; J Herbert Patterson; Christopher M O'Connor
Journal:  Heart Fail Rev       Date:  2010-07       Impact factor: 4.214

9.  Experimental model of transthoracic, vascular-targeted, photodynamically induced myocardial infarction.

Authors:  Adrian Chrastina; Peter Pokreisz; Jan E Schnitzer
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-11-08       Impact factor: 4.733

10.  Single molecule studies of multiple-fluorophore labeled antibodies. Effect of homo-FRET on the number of photons available before photobleaching.

Authors:  Rafal Luchowski; Evgenia G Matveeva; Ignacy Gryczynski; Ewald A Terpetschnig; Leonid Patsenker; Gabor Laczko; Julian Borejdo; Zygmunt Gryczynski
Journal:  Curr Pharm Biotechnol       Date:  2008-10       Impact factor: 2.837
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