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Literature DB >> 16275953

Immunogenicity of fowlpox virus expressing the avian influenza virus H5 gene (TROVAC AIV-H5) in cats.

Kemal Karaca¹, David E Swayne, Deborah Grosenbaugh, Michel Bublot, Amy Robles, Erica Spackman, Robert Nordgren.

Abstract

Vaccination of cats with fowlpox virus expressing the avian influenza (AI) virus H5 hemagglutinin gene (TROVAC AI) resulted in detectable hemagglutination inhibition (HI) antibody responses to the homologous A/Turkey/Ireland/1378/83 (H5N8) (A/tky/Ire/83) AI virus antigen. The HI antibody responses to heterologous A/Chicken/Indonesia/7/03 (H5N1) (A/ck/Indonesia/03) AI virus antigen were also detected in all vaccinated cats, but only after booster vaccinations. The vaccine described in this study and other poxvirus-vectored vaccines may be of value for the prophylaxis of AI virus-associated morbidity and mortality in mammals.

Entities: Species

Mesh：

Substances：

Year: 2005 PMID： 16275953 PMCID： PMC1287764 DOI： 10.1128/CDLI.12.11.1340-1342.2005

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

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