Literature DB >> 16275844

Serum anticholinergic activity, white matter hyperintensities, and cognitive performance.

R D Nebes1, B G Pollock, C C Meltzer, J A Saxton, P R Houck, E M Halligan, S T DeKosky.   

Abstract

The authors investigated whether the cognitive impairments associated with white matter hyperintensities (WMH) in normal elderly subjects are exacerbated by any anticholinergic medications being taken by the subjects. Results showed serum anticholinergic activity (SAA) and WMH volume to have a synergistic interaction such that the cognitive decrements associated with increasing WMH volume were greatest in those older individuals in the highest quartile of the SAA distribution.

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Year:  2005        PMID： 16275844     DOI： 10.1212/01.wnl.0000183152.16690.26

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk.

Authors:  Robert D Nebes; Bruce G Pollock; Subashan Perera; Edythe M Halligan; Judith A Saxton
Journal:  Am J Geriatr Pharmacother       Date:  2012-04-24

2.  Association between anticholinergic (atropinic) drug exposure and cognitive function in longitudinal studies among individuals over 50 years old: a systematic review.

Authors:  Laurine Andre; Adeline Gallini; François Montastruc; Jean-Louis Montastruc; Antoine Piau; Maryse Lapeyre-Mestre; Virginie Gardette
Journal:  Eur J Clin Pharmacol       Date:  2019-08-29       Impact factor: 2.953

3.  Central Anticholinergic Adverse Effects and Their Measurement.

Authors:  Pasi Lampela; Teemu Paajanen; Sirpa Hartikainen; Risto Huupponen
Journal:  Drugs Aging       Date:  2015-12       Impact factor: 3.923

4.  Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use.

Authors:  Robert D Nebes; Bruce G Pollock; Edythe M Halligan; Patricia Houck; Judith A Saxton
Journal:  Am J Geriatr Psychiatry       Date:  2011-02       Impact factor: 4.105

5.  Aging changes and medical complexity in late-life bipolar disorder: emerging research findings that may help advance care.

Authors:  Martha Sajatovic; Brent P Forester; Ariel Gildengers; Benoit H Mulsant
Journal:  Neuropsychiatry (London)       Date:  2013-12-01

6.  Prefrontal gray matter morphology mediates the association between serum anticholinergicity and cognitive functioning in early course schizophrenia.

Authors:  Jessica A Wojtalik; Shaun M Eack; Bruce G Pollock; Matcheri S Keshavan
Journal:  Psychiatry Res       Date:  2012-11-15       Impact factor: 3.222

7.  The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia.

Authors:  Sophia Vinogradov; Melissa Fisher; Heather Warm; Christine Holland; Margaret A Kirshner; Bruce G Pollock
Journal:  Am J Psychiatry       Date:  2009-07-01       Impact factor: 18.112

8.  Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study.

Authors:  Isabelle Carrière; Annie Fourrier-Reglat; Jean-François Dartigues; Olivier Rouaud; Florence Pasquier; Karen Ritchie; Marie-Laure Ancelin
Journal:  Arch Intern Med       Date:  2009-07-27

Review 9.  The cognitive impact of anticholinergics: a clinical review.

Authors:  Noll Campbell; Malaz Boustani; Tony Limbil; Carol Ott; Chris Fox; Ian Maidment; Cathy C Schubert; Stephanie Munger; Donna Fick; David Miller; Rajesh Gulati
Journal:  Clin Interv Aging       Date:  2009-06-09       Impact factor: 4.458

10.  Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium.

Authors:  Christine Thomas; Ute Hestermann; Juergen Kopitz; Konstanze Plaschke; Peter Oster; Martin Driessen; Christoph Mundt; Matthias Weisbrod
Journal:  BMC Neurosci       Date:  2008-09-15       Impact factor: 3.288
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