| Literature DB >> 16275083 |
Xia Zhou1, Baoan Song, Linhong Jin, Deyu Hu, Chunling Diao, Guangfang Xu, Zhihui Zou, Song Yang.
Abstract
Five hydroxyanthraquinone compounds were purified from Chinese medicinal herb rhubarb by microwave-assisted extraction and silica gel column isolation. Their structures were identified by spectroscopic analysis. One of them, emodin, was found to block the ERK phosphorylation of PC3 cells at 20 microM. And two other compounds had potent proliferation inhibitory activity on A431 and PC3 cells at 20 microM. Furthermore, crude extracts revealed an antifungal activity stronger than that of purified compounds against several plant pathogens tested. Together, our study suggests that these compounds are biologically active and may lead to development of anticancer medicine.Entities:
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Year: 2005 PMID： 16275083 DOI： 10.1016/j.bmcl.2005.10.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823