| Literature DB >> 16275076 |
Zhong Chen1, Soong-Hoon Kim, Stephanie A Barbosa, Tram Huynh, David R Tortolani, Kenneth J Leavitt, Donna D Wei, Veeraswamy Manne, Carolyn S Ricca, Johnni Gullo-Brown, Michael A Poss, Wayne Vaccaro, Mark E Salvati.
Abstract
The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.Entities:
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Year: 2005 PMID： 16275076 DOI： 10.1016/j.bmcl.2005.10.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823