Literature DB >> 16275074

Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.

Nikhil H Gokhale1, K Shirisha, Subhash B Padhye, Simon L Croft, Howard D Kendrick, Vickie Mckee.   

Abstract

The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.

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Year:  2005        PMID： 16275074     DOI： 10.1016/j.bmcl.2005.09.061

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases.

Authors:  Saliu A Amolegbe; Caroline A Akinremi; Sheriff Adewuyi; Amudat Lawal; Mercy O Bamigboye; Joshua A Obaleye
Journal:  J Biol Inorg Chem       Date:  2016-11-30       Impact factor: 3.358

2.  Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum.

Authors:  Subash Chandra Mohapatra; Hemandra Kumar Tiwari; Manisha Singla; Brijesh Rathi; Arun Sharma; Kuldeep Mahiya; Mukesh Kumar; Saket Sinha; Shyam Singh Chauhan
Journal:  J Biol Inorg Chem       Date:  2009-11-28       Impact factor: 3.358

3.  Aminequinone-hydroxylquinoneimine tautomeric equilibrium revisited: molecular modeling study of the tautomeric equilibrium and substituent effects in 4-(4-R-phenylamino)naphthalene-1,2-diones.

Authors:  Thaís P Fragoso; José Walkimar de Mesquita Carneiro; Maria D Vargas
Journal:  J Mol Model       Date:  2009-09-13       Impact factor: 1.810
  3 in total

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