| Literature DB >> 16274873 |
Alain Valla1, Benoist Valla, Dominique Cartier, Régis Le Guillou, Roger Labia, Loic Florent, Sébastien Charneau, Joseph Schrevel, Pierre Potier.
Abstract
A series of 'retinoid-like chalcones' and diverse derivatives relative to licochalcone A were synthesized from a new enaminone synthon. These syntheses occurred via a new aromatic annelation. These new derivatives have been tested in vitro as potential antimalarial agents. The 4-hydroxy-chalcone-like (compound 6a, derived from beta-ionone) exhibits a good and reproducible inhibitory effect on the in vitro culture of Plasmodium falciparum, with an IC 50 lower than 10 microM for inhibition of 3H-hypoxanthine uptake by parasites (respectively, 4.93 and 8.47 microM for strains K1 and Thaï).Entities:
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Year: 2005 PMID： 16274873 DOI： 10.1016/j.ejmech.2005.05.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514