Literature DB >> 16274848

Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins.

Brent E Wisse1, Kayoko Ogimoto, Michael W Schwartz.   

Abstract

In the current study we sought to determine whether hypothalamic IL-1beta is regulated by melanocortin signaling and if melanocortin-induced changes in energy balance are dependent on IL-1beta. A melanocortin agonist, MTII, increased hypothalamic IL-1beta mRNA levels by two-fold, whereas a melanocortin antagonist, SHU9119, blunted lipopolysaccharide (LPS)-mediated increase of hypothalamic IL-1beta content. Pharmacological or genetic disruption of IL-1 receptor signaling prevented MTII-mediated reductions in locomotor activity, but did not reduce MTII-induced anorexia. These data suggest a potential role for central melanocortins in mediating the decrease of ambulation characteristic of the 'sickness' response.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16274848     DOI： 10.1016/j.peptides.2005.08.020

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  10 in total

Review 1.  POMC Neurons: From Birth to Death.

Authors:  Chitoku Toda; Anna Santoro; Jung Dae Kim; Sabrina Diano
Journal:  Annu Rev Physiol       Date:  2017-02-10       Impact factor: 19.318

2.  Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Authors:  Beth Lute; William Jou; Dalya M Lateef; Margalit Goldgof; Cuiying Xiao; Ramón A Piñol; Alexxai V Kravitz; Nicole R Miller; Yuning George Huang; Clemence Girardet; Andrew A Butler; Oksana Gavrilova; Marc L Reitman
Journal:  Cell Metab       Date:  2014-06-26       Impact factor: 27.287

3.  Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice.

Authors:  Sun Ju Choi; Zipora Yablonka-Reuveni; Karl J Kaiyala; Kayoko Ogimoto; Michael W Schwartz; Brent E Wisse
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-03-22       Impact factor: 4.310

4.  Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance.

Authors:  Brent E Wisse; Kayoko Ogimoto; Gregory J Morton; Diana L Williams; Michael W Schwartz
Journal:  Brain Res       Date:  2007-01-27       Impact factor: 3.252

5.  Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6.

Authors:  Rozita Shirazi; Vilborg Palsdottir; Jim Collander; Fredrik Anesten; Heike Vogel; Fanny Langlet; Alexander Jaschke; Annette Schürmann; Vincent Prévot; Ruijin Shao; John-Olov Jansson; Karolina Patrycja Skibicka
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-18       Impact factor: 11.205

6.  Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.

Authors:  Joshua P Thaler; Sun Ju Choi; Mini P Sajan; Kayoko Ogimoto; Hong T Nguyen; Miles Matsen; Stephen C Benoit; Brent E Wisse; Robert V Farese; Michael W Schwartz
Journal:  Endocrinology       Date:  2009-10-09       Impact factor: 4.736

7.  Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration.

Authors:  Keith W Whitaker; Teresa M Reyes
Journal:  Neuropharmacology       Date:  2007-11-05       Impact factor: 5.250

8.  Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice.

Authors:  Karl J Kaiyala; Gregory J Morton; Joshua P Thaler; Thomas H Meek; Tracy Tylee; Kayoko Ogimoto; Brent E Wisse
Journal:  PLoS One       Date:  2012-08-22       Impact factor: 3.240

9.  Central and peripheral effects of physical exercise without weight reduction in obese and lean mice.

Authors:  Francine Pereira de Carvalho; Thaís Ludmilla Moretto; Izabelle Dias Benfato; Marcela Barthichoto; Sandra Mara Ferreira; José Maria Costa-Júnior; Camila Aparecida Machado de Oliveira
Journal:  Biosci Rep       Date:  2018-03-05       Impact factor: 3.840

10.  Cytokines and Neurodegeneration in Epileptogenesis.

Authors:  Pawel Wolinski; Dominika Ksiazek-Winiarek; Andrzej Glabinski
Journal:  Brain Sci       Date:  2022-03-12
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.