OBJECTIVES: Vacuolar myelopathy is the major cause of spinal cord disease in HIV-1 infection. However, the pathogenesis remains unclear. Diagnosis is mainly based on characteristic clinical symptoms in combination with characteristic MRI changes. Usually, it is a slowly progressive chronic disease affecting HIV-infected individuals with low CD4 T-cell counts. CASE: Here, we report an uncommon case of vacuolar myelopathy in an HIV-infected woman with recurrent clinical symptoms and MRI changes of vacuolar myelopathy and with a preserved CD4 T-cell count when symptoms occurred for the first time. CONCLUSIONS: This is the first case, to show that vacuolar myelopathy can have relapsing-remitting clinical symptoms and MRI changes.
OBJECTIVES:Vacuolar myelopathy is the major cause of spinal cord disease in HIV-1 infection. However, the pathogenesis remains unclear. Diagnosis is mainly based on characteristic clinical symptoms in combination with characteristic MRI changes. Usually, it is a slowly progressive chronic disease affecting HIV-infected individuals with low CD4 T-cell counts. CASE: Here, we report an uncommon case of vacuolar myelopathy in an HIV-infectedwoman with recurrent clinical symptoms and MRI changes of vacuolar myelopathy and with a preserved CD4 T-cell count when symptoms occurred for the first time. CONCLUSIONS: This is the first case, to show that vacuolar myelopathy can have relapsing-remitting clinical symptoms and MRI changes.
Authors: Christina Mueller-Mang; Meng Law; Thomas Mang; Julia Fruehwald-Pallamar; Michael Weber; Majda M Thurnher Journal: Neuroradiology Date: 2010-11-03 Impact factor: 2.804