Literature DB >> 16273102

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.

Ronald S Veazey1, Martin S Springer, Preston A Marx, Jason Dufour, Per Johan Klasse, John P Moore.   

Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

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Year:  2005        PMID： 16273102     DOI： 10.1038/nm1321

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  41 in total

1.  Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

Authors:  Ronald S Veazey; Thomas A Ketas; Per Johan Klasse; Donna K Davison; Morgan Singletary; Linda C Green; Michael L Greenberg; John P Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-22       Impact factor: 11.205

2.  Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.

Authors:  R Karl Malcolm; Deborah Lowry; Peter Boyd; Leslie Geer; Ronald S Veazey; Laurie Goldman; P J Klasse; Robin J Shattock; John P Moore
Journal:  J Antimicrob Chemother       Date:  2013-12-30       Impact factor: 5.790

3.  Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissues.

Authors:  Ivana Massud; Wutyi Aung; Amy Martin; Shanon Bachman; James Mitchell; Rachael Aubert; Theodros Solomon Tsegaye; Ellen Kersh; Chou-Pong Pau; Walid Heneine; J Gerardo García-Lerma
Journal:  J Virol       Date:  2013-06-05       Impact factor: 5.103

Review 4.  Risk compensation in HIV prevention: implications for vaccines, microbicides, and other biomedical HIV prevention technologies.

Authors:  Lisa A Eaton; Seth Kalichman
Journal:  Curr HIV/AIDS Rep       Date:  2007-12       Impact factor: 5.071

5.  Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor.

Authors:  Ronald S Veazey; Thomas J Ketas; Jason Dufour; Terri Moroney-Rasmussen; Linda C Green; P J Klasse; John P Moore
Journal:  J Infect Dis       Date:  2010-09-01       Impact factor: 5.226

6.  Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.

Authors:  R Karl Malcolm; Claire J Forbes; Leslie Geer; Ronald S Veazey; Laurie Goldman; Per Johan Klasse; John P Moore
Journal:  J Antimicrob Chemother       Date:  2012-10-30       Impact factor: 5.790

7.  A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.

Authors:  Chasity D Andrews; Yun Lan Yueh; William R Spreen; Leslie St Bernard; Mar Boente-Carrera; Kristina Rodriguez; Agegnehu Gettie; Kasi Russell-Lodrigue; James Blanchard; Susan Ford; Hiroshi Mohri; Cecilia Cheng-Mayer; Zhi Hong; David D Ho; Martin Markowitz
Journal:  Sci Transl Med       Date:  2015-01-14       Impact factor: 17.956

8.  Infection of macrophages and dendritic cells with primary R5-tropic human immunodeficiency virus type 1 inhibited by natural polyreactive anti-CCR5 antibodies purified from cervicovaginal secretions.

Authors:  Jobin Eslahpazir; Mohammad-Ali Jenabian; Hicham Bouhlal; Hakim Hocini; Cédric Carbonneil; Gérard Grésenguet; François-Xavier Mbopi Kéou; Jérôme LeGoff; Héla Saïdi; Mary Requena; Nadine Nasreddine; Jean de Dieu Longo; Srinivas V Kaveri; Laurent Bélec
Journal:  Clin Vaccine Immunol       Date:  2008-03-19

9.  Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques.

Authors:  Dawn M Dudley; Jennifer L Wentzel; Matthew S Lalonde; Ronald S Veazey; Eric J Arts
Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

10.  Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.

Authors:  Paul W Denton; John F Krisko; Daniel A Powell; Melissa Mathias; Youn Tae Kwak; Francisco Martinez-Torres; Wei Zou; Deborah A Payne; Jacob D Estes; J Victor Garcia
Journal:  PLoS One       Date:  2010-01-21       Impact factor: 3.240
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