| Literature DB >> 1627212 |
R S Sperling1, J Roboz, R Dische, D Silides, I Holzman, E Jew.
Abstract
As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.Entities:
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Year: 1992 PMID： 1627212 DOI： 10.1055/s-2007-994781
Source DB: PubMed Journal: Am J Perinatol ISSN： 0735-1631 Impact factor: 1.862