| Literature DB >> 16271938 |
T N Egbe-Nwiyi1, I O Igbokwe, P A Onyeyili.
Abstract
Four groups (A, B, C and D) of 10 naïve rats were used to compare the virulence of isolates of a strain of Trypanosoma brucei before and after the development of diminazene aceturate resistance. Group A rats were uninfected (controls). Group B rats were infected with a trypanosome isolate unexposed to the drug, while groups C and D rats were infected with two different drug-resistant isolates of the same strain. Rats in the three infected groups each received 10(6) trypanosomes intraperitoneally. Prepatent periods were longer (P<0.05) in groups C and D than in group B. The parasitaemic periods in groups B, C and D were similar, but group C and D rats differed from group B rats in surviving longer, and in showing lower degrees of parasitaemia, anaemia and hepatomegaly. No differences were noted between group C and D rats. Thus, diminazene aceturate resistance appeared to reduce the virulence of T. brucei.Entities:
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Year: 2005 PMID： 16271938 DOI： 10.1016/j.jcpa.2005.05.002
Source DB: PubMed Journal: J Comp Pathol ISSN： 0021-9975 Impact factor: 1.311