| Literature DB >> 16271528 |
Abstract
Resveratrol induces longevity in C. elegans through the action of SIR2. Recently published work shows that resveratrol induces genes of the unfolded protein stress response of the endoplasmic reticulum. Paradoxically, these stress genes are repressed by SIR2, suggesting that resveratrol increases life span by inhibiting this SIR2 action.Entities:
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Year: 2005 PMID： 16271528 DOI： 10.1016/j.cmet.2005.10.006
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287