| Literature DB >> 16271524 |
Abstract
The molecular mechanisms whereby PPARgamma inhibits inflammatory gene expression in macrophages are poorly understood. In a recent Nature paper, provide a new model for trans-repression in which ligand-dependent SUMOylation of PPARgamma results in its recruitment to the promoters of inflammatory genes where it inhibits transcription by preventing clearance of corepressor complexes.Entities:
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Year: 2005 PMID： 16271524 DOI： 10.1016/j.cmet.2005.10.004
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287